Dinuclear metal complexes have emerged as a promising class of unusually biologically active compounds. Acylpyrazolonato-bridged arene ruthenium complexes of the general formula [(arene)2Ru2(L')Cl2] were synthesized in methanol by reacting the arene ruthenium dimer [(arene)RuCl2]2 with the corresponding acylpyrazolone ligands. The complexes were isolated and fully characterized by spectroscopic methods; the single-crystal X-ray structure analysis of [(cymene)2Ru2(L1)Cl2] is also presented. These ruthenium complexes were found to be cytotoxic towards epithelial cancerous cell lines to a comparable extent to cisplatin but with higher capacity to discriminate between normal and cancer cells.

Dinuclear (h6-arene) ruthenium(II) acylpyrazolone complexes: Synthesis, characterization and cytotoxicity

PETTINARI, Riccardo;MARCHETTI, Fabio;PETTINARI, Claudio;PETRINI, Agnese;BONFILI, LAURA;CUCCIOLONI, Massimiliano;ELEUTERI, Anna Maria
2015

Abstract

Dinuclear metal complexes have emerged as a promising class of unusually biologically active compounds. Acylpyrazolonato-bridged arene ruthenium complexes of the general formula [(arene)2Ru2(L')Cl2] were synthesized in methanol by reacting the arene ruthenium dimer [(arene)RuCl2]2 with the corresponding acylpyrazolone ligands. The complexes were isolated and fully characterized by spectroscopic methods; the single-crystal X-ray structure analysis of [(cymene)2Ru2(L1)Cl2] is also presented. These ruthenium complexes were found to be cytotoxic towards epithelial cancerous cell lines to a comparable extent to cisplatin but with higher capacity to discriminate between normal and cancer cells.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/382181
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