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|Titolo:||Evaluation of anticancer properties of thiosugars|
|Autori interni:||PETRELLI, Riccardo|
|Data di pubblicazione:||2015|
|Abstract:||The “sugar code” concept assumes the interaction of carbohydrates with inter and intra cellular components. This concept is the basis of a therapy employing carbohydrate-derived chemicals as drugs (Gabius, 2004). The “CARB” pharmacological potential is enhanced by the addition of pharmacophores and other functional groups. We proposed an idea of “functional carb-pharmacophores” (FCP) as a new approach to compose functionalized sugar derivatives that have therapeutic potential (Witczak, Poplawski, 2014) and designed the collection of FCP. For further investigation we choose sugar derivatives including thisugar and 1-4-S-thiodisacharide motifs. Our preliminary data suggest their anticancer properties, and the most sensitive was astrocytoma (HTB-14) and breast cancer (MCF-7) cell lines. The aim of this project is to determine mechanisms of anticancer activities of functional carb-pharmacophores (FCPs). Taking into account the results of our research we set the following hypotheses: The selected FCPs kills cancer cells by activating one of the cellular death pathway. The selected FCPs induce expression of the key genes in biological pathways activated in response to toxic drugs in cancer and normal cells The selected FCPs induce oxidative stress in cancer cells. The selected FCPs have inhibitory effect on proliferation cancer cells in vitro The uptake of selected FCPs is mediated by facilitative glucose transporter proteins (GLUTs).|
|Appare nelle tipologie:||REVISIONE DI PROGETTI|
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