Nucleoside kinases, 5'-nucleotidases, and cytidine and deoxycytidine monophosphate deaminases participate in the regulation of cellular nucleotide and nucleoside pools and also in the metabolism of therapeutically significant nucleoside and nucleotide analogs. Some of these enzymes represent promising therapeutic targets as their inhibition may increase the effectiveness of cancer chemotherapy and/or antiviral treatment. In this project, we will focus on the development of (i) new inhibitors of cytidine and deoxycytidine monophosphate deaminases and 5'-nucleotidases and (ii) new methods enabling fast, cheap and high throughput screening of cytidine and deoxycytidine monophosphate deaminases and 5'-nucleotidases activities.
New inhibitors and new high throughput systems of analysis of nucleoside(-tide) metabolism
CAPPELLACCI, Loredana
2015-01-01
Abstract
Nucleoside kinases, 5'-nucleotidases, and cytidine and deoxycytidine monophosphate deaminases participate in the regulation of cellular nucleotide and nucleoside pools and also in the metabolism of therapeutically significant nucleoside and nucleotide analogs. Some of these enzymes represent promising therapeutic targets as their inhibition may increase the effectiveness of cancer chemotherapy and/or antiviral treatment. In this project, we will focus on the development of (i) new inhibitors of cytidine and deoxycytidine monophosphate deaminases and 5'-nucleotidases and (ii) new methods enabling fast, cheap and high throughput screening of cytidine and deoxycytidine monophosphate deaminases and 5'-nucleotidases activities.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
