Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes with N,O-Chelating Pyrazolone-Based β-Ketoamine Ligands

Pettinari, Riccardo; Marchetti, Fabio; Pettinari, Claudio; Petrini, Agnese; Rosario, Scopelliti; Clavel, Catherine M.; Dyson, Paul J.

doi:10.1021/ic502274b

Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based β-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by singlecrystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.

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Titolo:	Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes with N,O-Chelating Pyrazolone-Based β-Ketoamine Ligands
Autori:	PETTINARI, Riccardo MARCHETTI, Fabio PETTINARI, Claudio PETRINI, Agnese Rosario Scopelliti Catherine M. Clavel Paul J. Dyson mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2014
Rivista:	INORGANIC CHEMISTRY
Abstract:	Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based β-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by singlecrystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.
Handle:	http://hdl.handle.net/11581/351381
Appare nelle tipologie:	Articolo

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