Reaction of alpha-amido sulfones with nitro ketals promoted by KF on alumina provides the corresponding adducts which, upon treatment with p-toluenesulfonic acid, generate the corresponding N-alkoxycarbonyl-2,5-disubstituted pyrroles. The latter transformation involves a cascade process including ketal cleavage, ring closure and final aromatization by nitrous acid elimination.

Reaction of alpha-amido sulfones with functionalized nitrocompounds: a new two-step synthesis of Nalkoxycarbonyl-2,5-disubstituted pyrroles

BALLINI, Roberto;GABRIELLI, Serena;PALMIERI, Alessandro;PETRINI, Marino
2014

Abstract

Reaction of alpha-amido sulfones with nitro ketals promoted by KF on alumina provides the corresponding adducts which, upon treatment with p-toluenesulfonic acid, generate the corresponding N-alkoxycarbonyl-2,5-disubstituted pyrroles. The latter transformation involves a cascade process including ketal cleavage, ring closure and final aromatization by nitrous acid elimination.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/338190
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