Assessment of Botulinum a Toxin High Affinity SV2 Receptors on Normal Human Urothelial Cells.

Giannantoni, A; Proietti, S; Vianello, A; Amantini, Consuelo; Farfariello, Valerio; Santoni, Giorgio; Porena, M.

The clinical use of Botulinum A toxin (BoNT/A) is based on its ability to block the vesicular release of Acetilcholine (Ach) and other neurotransmitters at the level of the neuronal plasmatic membrane. This process requires the internalization of the neurotoxin within the target cell, what it happens by means of the binding with high affinity receptors. These receptors are the synaptic vesicle proteins type 2 (SV2). To date three different types of SV2 receptors have been identified in synaptic structures and endocrine tissues.

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Titolo:	Assessment of Botulinum a Toxin High Affinity SV2 Receptors on Normal Human Urothelial Cells.
Autori:	Giannantoni A Proietti S Vianello A AMANTINI, Consuelo FARFARIELLO, Valerio SANTONI, Giorgio Porena M. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2011
Rivista:	THE JOURNAL OF UROLOGY
Abstract:	The clinical use of Botulinum A toxin (BoNT/A) is based on its ability to block the vesicular release of Acetilcholine (Ach) and other neurotransmitters at the level of the neuronal plasmatic membrane. This process requires the internalization of the neurotoxin within the target cell, what it happens by means of the binding with high affinity receptors. These receptors are the synaptic vesicle proteins type 2 (SV2). To date three different types of SV2 receptors have been identified in synaptic structures and endocrine tissues.
Handle:	http://hdl.handle.net/11581/333995
Appare nelle tipologie:	Poster atto convegno su rivista

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