A randomised, double-blind, placebo-controlled, parallel groups study assessed the effects of daily consumption of the probiotic combination SYNBIO®, by probiotic-enriched foods or by dietary supplement on bowel habits of healthy adults. Primary and secondary outcomes gave the overall assessment of bowel well-being, a self-administration of Psychological General Well-Being Index (PGWBI) estimated the health-related quality of life as well as the gastrointestinal tolerance determined with the Gastrointestinal Symptom Rating Scale (GSRS). Support Vector Machines models for classification problems have been used to validate the total outcomes on the bowel well-being. SYNBIO® consumption improved bowel habits of volunteers consuming the probiotic foods or capsules and the same effects were not registered in the control groups. The recovery of probiotic bacteria from the faeces of a cohort of 100 subjects for each supplemented group showed the persistence of strains in the gastrointestinal tract.

Probiotic-enriched foods and dietary supplement containing SYNBIO positively affects bowel habits in healthy adults: an assessment using standard statistical analysis and Support Vector Machines

SILVI, Stefania;VERDENELLI, Maria Cristina;CECCHINI, Cinzia;COMAN, MARIA MAGDALENA;BERNABEI, Maria Simonetta;ROSATI, JESSICA;DE LEONE, Renato;ORPIANESI, Carla;CRESCI, Alberto
2014-01-01

Abstract

A randomised, double-blind, placebo-controlled, parallel groups study assessed the effects of daily consumption of the probiotic combination SYNBIO®, by probiotic-enriched foods or by dietary supplement on bowel habits of healthy adults. Primary and secondary outcomes gave the overall assessment of bowel well-being, a self-administration of Psychological General Well-Being Index (PGWBI) estimated the health-related quality of life as well as the gastrointestinal tolerance determined with the Gastrointestinal Symptom Rating Scale (GSRS). Support Vector Machines models for classification problems have been used to validate the total outcomes on the bowel well-being. SYNBIO® consumption improved bowel habits of volunteers consuming the probiotic foods or capsules and the same effects were not registered in the control groups. The recovery of probiotic bacteria from the faeces of a cohort of 100 subjects for each supplemented group showed the persistence of strains in the gastrointestinal tract.
2014
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/326582
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