The aim of this study is to gain more knowledge on the impact of early life pesticide exposure on premature aging. The effect of a low dose of the insecticide permethrin administered to rats during early life (1/50 LD50, from 6th to 21st day of life) was analyzed by measuring some metabolites in plasma and urine of 500- day-old animals. Significant differences in early life treated rats compared to the control group were found in the plasma levels of Ca++, Na+, 25-hydroxy-vitamin D, adrenaline, noradrenaline, nitric oxide, cholesterol and urea while in urine only Na+ content was different. These results add information on the impact of permethrin during the neonatal period, supporting the evidence that early life environmental exposure to xenobiotics has long-term effects, inducing modifications in adulthood that can be revealed by the analysis of some macroelements, metabolites and catecholamines in plasma, when rats are 500 days old.
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|Titolo:||Early life permethrin exposure leads to hypervitaminosis D, nitric oxide and catecholamines impairment|
|Data di pubblicazione:||2013|
|Appare nelle tipologie:||Articolo|