The reaction of sulfonylpyrroles with nitroalkanes in the presence of KF/alumina generates 3-(2-nitroalkyl)pyrroles in good yields. These compounds can be converted into trisubstituted 6-azaindoles by a sequence of reactions comprising reduction of the nitro group, Pictet–Spengler cyclization and final oxidative aromatization.

Synthesis of 3-(2-Nitroalkyl)pyrroles from Sulfonylpyrroles and their Conversion to 6-Azaindole Derivatives

LANCIANESI, STEFANO;PALMIERI, Alessandro;PETRINI, Marino
2013-01-01

Abstract

The reaction of sulfonylpyrroles with nitroalkanes in the presence of KF/alumina generates 3-(2-nitroalkyl)pyrroles in good yields. These compounds can be converted into trisubstituted 6-azaindoles by a sequence of reactions comprising reduction of the nitro group, Pictet–Spengler cyclization and final oxidative aromatization.
2013
262
File in questo prodotto:
File Dimensione Formato  
ASC2013,3285.pdf

solo gestori di archivio

Tipologia: Versione Editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 181.01 kB
Formato Adobe PDF
181.01 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/289181
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 12
social impact