The reaction of sulfonylpyrroles with nitroalkanes in the presence of KF/alumina generates 3-(2-nitroalkyl)pyrroles in good yields. These compounds can be converted into trisubstituted 6-azaindoles by a sequence of reactions comprising reduction of the nitro group, Pictet–Spengler cyclization and final oxidative aromatization.
Synthesis of 3-(2-Nitroalkyl)pyrroles from Sulfonylpyrroles and their Conversion to 6-Azaindole Derivatives
LANCIANESI, STEFANO;PALMIERI, Alessandro;PETRINI, Marino
2013-01-01
Abstract
The reaction of sulfonylpyrroles with nitroalkanes in the presence of KF/alumina generates 3-(2-nitroalkyl)pyrroles in good yields. These compounds can be converted into trisubstituted 6-azaindoles by a sequence of reactions comprising reduction of the nitro group, Pictet–Spengler cyclization and final oxidative aromatization.File in questo prodotto:
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