Thetransientreceptorpotentialvanilloidtype-2(TRPV2),belongingtothetransientreceptorpotentialchannelfamily,isaspecializedionchannelexpressedinhumanandothermammalianimmunecells.ThischannelhasbeenfoundtobeexpressedinCD34+hematopoieticstemcells,whereitscytosolicCa2+activityiscrucialforstem/progenitorcellcycleprogression,growth,anddifferentiation.Ininnateimmunecells,TRPV2isexpressedingranulocytes,macrophages,andmonocyteswhereitstimulatesfMet-Leu-Phemigration,zymosan-,immunoglobulinG-,andcomplement-mediatedphagocytosis,andlipopolysaccharide-inducedtumornecrosisfactor-alphaandinterleukin-6production.Inmastcells,activationofTRPV2allowsintracellularCa2+ionsflux,thusstimulatingproteinkinaseA-dependentdegranulation.Inaddition,TRPV2ishighlyexpressedinCD56+naturalkillercells.TRPV2orchestratesCa2+signalinTcellactivation,proliferation,andeffectorfunctions.Moreover,messengerRNAforTRPV2areexpressedinCD4+andCD8+Tlymphocytes.Finally,TRPV2isexpressedinCD19+BlymphocyteswhereitregulatesCa2+releaseduringBcelldevelopmentandactivation.Overall,thespecificexpressionofTRPV2inimmunecellssuggestsaroleinimmune-mediateddiseasesandoffersnewpotentialtargetsforimmunomodulation.
The role of transient receptor potential vanilloid type-2 ion channels in innate and adaptive immune responses.
SANTONI, Giorgio;FARFARIELLO, Valerio;LIBERATI, SONIA;Morelli MB;NABISSI, MASSIMO;AMANTINI, Consuelo
2013-01-01
Abstract
Thetransientreceptorpotentialvanilloidtype-2(TRPV2),belongingtothetransientreceptorpotentialchannelfamily,isaspecializedionchannelexpressedinhumanandothermammalianimmunecells.ThischannelhasbeenfoundtobeexpressedinCD34+hematopoieticstemcells,whereitscytosolicCa2+activityiscrucialforstem/progenitorcellcycleprogression,growth,anddifferentiation.Ininnateimmunecells,TRPV2isexpressedingranulocytes,macrophages,andmonocyteswhereitstimulatesfMet-Leu-Phemigration,zymosan-,immunoglobulinG-,andcomplement-mediatedphagocytosis,andlipopolysaccharide-inducedtumornecrosisfactor-alphaandinterleukin-6production.Inmastcells,activationofTRPV2allowsintracellularCa2+ionsflux,thusstimulatingproteinkinaseA-dependentdegranulation.Inaddition,TRPV2ishighlyexpressedinCD56+naturalkillercells.TRPV2orchestratesCa2+signalinTcellactivation,proliferation,andeffectorfunctions.Moreover,messengerRNAforTRPV2areexpressedinCD4+andCD8+Tlymphocytes.Finally,TRPV2isexpressedinCD19+BlymphocyteswhereitregulatesCa2+releaseduringBcelldevelopmentandactivation.Overall,thespecificexpressionofTRPV2inimmunecellssuggestsaroleinimmune-mediateddiseasesandoffersnewpotentialtargetsforimmunomodulation.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
