SUMMARY - Tlie p53 protein is a transcription factor inducing celi cycle arresi and apoptosis against a DNA damage. p53 mutations might lead to lose its inibitoring growth functions and contribute to not controlied cellular proliferation. Mutations and/or overexpression of p53 are thè most comnion genetic alterations found in human cancer. The role of thè p53 protein in cancerogenesis m domestic animals is stili largely unknown. This prelimmary study investigates thè expression of p?3 in 16 semmomas of thè dog using a standard streptavidinbiotin peroxidase method after microwave antigen retrieval. In 9 diffuse seminomas tlie mtensity of p53 expression is of low degree (^), in 5 diffuse seminomas is of middle degree (++) and m 2 intratubular seminomas is of higt degree (+++). The results suggest tlie p53 expression m seminoma of thè dog decreases with advancing stage of neoplastic process.

Indagini preliminari sull’espressione immunoistochimica della proteina p53 nel seminoma del cane

MARIOTTI, Francesca;
1997-01-01

Abstract

SUMMARY - Tlie p53 protein is a transcription factor inducing celi cycle arresi and apoptosis against a DNA damage. p53 mutations might lead to lose its inibitoring growth functions and contribute to not controlied cellular proliferation. Mutations and/or overexpression of p53 are thè most comnion genetic alterations found in human cancer. The role of thè p53 protein in cancerogenesis m domestic animals is stili largely unknown. This prelimmary study investigates thè expression of p?3 in 16 semmomas of thè dog using a standard streptavidinbiotin peroxidase method after microwave antigen retrieval. In 9 diffuse seminomas tlie mtensity of p53 expression is of low degree (^), in 5 diffuse seminomas is of middle degree (++) and m 2 intratubular seminomas is of higt degree (+++). The results suggest tlie p53 expression m seminoma of thè dog decreases with advancing stage of neoplastic process.
1997
262
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/279387
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact