SUMMARY - The Authors describe thè clinical, pathological and histotogical features of a case of squamous celi carcinoma (SCC) in a borse. A 13 year old, male, castrated, Irish horse, was kepi under observation after being sick for 9 months with thè following symptoms: dysoressia, chronic weight loss, sensory depression, pallor of thè apparent mucosae and, in thè last 30 days, diarrhoea, raeìena and diffuse oedemas. Physical and endoscopie examination and laboratory test» suggested a cachectic syndrome secondary to a neoplastic disease involving thè alimentary traci. Due to thè unfavourable prognosis, thè horse was euthanised according to thè owner's will, Anatomo-histopathological examination showed thè presence of stomach SCC. In this note thè Authors emphasize thè difficuity in diagnosing such neoplastic disease intra vitam.