Drug release from compressed Eudragit RS 30D coated beads

Palmieri, Giovanni Filippo; Pascal, Wehrlé; Sante, Martelli

Tablets of different hardnesses and compositions were prepared with an original theophylline granulate previously coated with Eudragit RS 30D. Dissolution studies of each tablet formulation were performed to verify any kinetic variationfrom the dissolution profile. This was obtained by filling with the same coated granules in a hard gelatine capsule. While the dissolution profiles of the capsules possesses very good linearity, the tablet kinetics gradually deviate from this linearity with an increase in the percentage of the coated granules in the formulation. Tablet hardness has only a marginal influence on this kinetic deviation.

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Titolo:	Drug release from compressed Eudragit RS 30D coated beads
Autori:	PALMIERI, Giovanni Filippo Pascal Wehrlé Sante Martelli mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	1996
Rivista:	STP PHARMA SCIENCES
Abstract:	Tablets of different hardnesses and compositions were prepared with an original theophylline granulate previously coated with Eudragit RS 30D. Dissolution studies of each tablet formulation were performed to verify any kinetic variationfrom the dissolution profile. This was obtained by filling with the same coated granules in a hard gelatine capsule. While the dissolution profiles of the capsules possesses very good linearity, the tablet kinetics gradually deviate from this linearity with an increase in the percentage of the coated granules in the formulation. Tablet hardness has only a marginal influence on this kinetic deviation.
Handle:	http://hdl.handle.net/11581/250614
Appare nelle tipologie:	Articolo

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