Interactions between b-cyclodextrin or hydroxypropyl b-cyclodextrin, as well as the possibility of obtaining inclusion complexes, were evaluated by several methods: a phase solubility diagram, high-power liquid chromatography, differential scanning calorimetry and X-ray diffractometry. Solid inclusion complexes were prepared by spray-drying, kneading and solid dispersion. The dissolution profiles of the obtained powders were studied in order to define the most appropriate cyclodextrin, preparation method and molar ratio to use in the production of a fenofibrate inclusion complex. Finally, tablets were prepared with the powder of the complex and characterized by dissolution studies.

Inclusion complexation of Fenofibrate with beta-cyclodextrin and hydroxypropyl beta-cyclodextrin. Evaluation of interactions in solution and solid complex characterization

PALMIERI, Giovanni Filippo;
1997-01-01

Abstract

Interactions between b-cyclodextrin or hydroxypropyl b-cyclodextrin, as well as the possibility of obtaining inclusion complexes, were evaluated by several methods: a phase solubility diagram, high-power liquid chromatography, differential scanning calorimetry and X-ray diffractometry. Solid inclusion complexes were prepared by spray-drying, kneading and solid dispersion. The dissolution profiles of the obtained powders were studied in order to define the most appropriate cyclodextrin, preparation method and molar ratio to use in the production of a fenofibrate inclusion complex. Finally, tablets were prepared with the powder of the complex and characterized by dissolution studies.
1997
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/250606
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