The effect of a low dose of the insecticide permethrin administered during early-life was evaluated on leukocytes inflammation mediators on 300- and 500-day-old rats. Nurr1, NF-κB-p65, Nrf2, lipid peroxidation and GSH levels increased with age but compared to the control group, treatment with permethrin induced a significant increase only of Nurr1 and lipid peroxidation in oldest rats. TNF-α and Rantes increased, while IL-1β, IL-2, IL-13 decreased in oldest treated rats. The results propose Nurr1, TNF-α, Rantes, GSH and plasma lipid peroxidation as peripheral biomarkers for monitoring the impact of early-life environmental exposure to xenobiotics in old age.
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|Titolo:||Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide|
|Data di pubblicazione:||2012|
|Citazione:||Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide / Donatella, Fedeli; Maura, Montani; Manuel, Carloni; Cinzia, Nasuti; Augusto, Amici; Rosita, Gabbianelli. - In: BIOMARKERS. - ISSN 1354-750X. - ELETTRONICO. - 17:7(2012), pp. 604-609.|
|Appare nelle tipologie:||Articolo|