A new alkylation method of enaminones (l-aryl-3- (isopropy1amino)-2-buten-1-ones) via addition of electrophiles to dianions of b-(isopropylamino)-a,b-enones, generated by treatment with 2.5 equivalents of 2,2,6.6-tetramethylpiperidinolithium, Li TMPITHF is reported. The reaction works well with alkyl halides and aldehydes while poor yields are obtained from ketones.
C-Alkylation of Dianions of beta-(isopropylamino)-alpha,beta enones
CIMARELLI, Cristina;PALMIERI, Gianni
1991-01-01
Abstract
A new alkylation method of enaminones (l-aryl-3- (isopropy1amino)-2-buten-1-ones) via addition of electrophiles to dianions of b-(isopropylamino)-a,b-enones, generated by treatment with 2.5 equivalents of 2,2,6.6-tetramethylpiperidinolithium, Li TMPITHF is reported. The reaction works well with alkyl halides and aldehydes while poor yields are obtained from ketones.File in questo prodotto:
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