A regioselective indirect alkylation of aminophenols to enantiopure tertiary aminophenols, which are useful chiral ligands for metal-catalysed asymmetric reactions, is reported. This very simple synthetic methodology, through reduction or alkylation of an intermediate benzoxazine, was performed in mild conditions, suitable for the conservation of the configuration of the stereogenic centres. Some crystalline aminophenols show the phenomenon of ‘crystallization-induced asymmetric transformation’.

Ready N-Alkylation Of Enantiopure Aminophenols: Synthesis Of Tertiary Aminophenols

CIMARELLI, Cristina;PALMIERI, Gianni;
2001-01-01

Abstract

A regioselective indirect alkylation of aminophenols to enantiopure tertiary aminophenols, which are useful chiral ligands for metal-catalysed asymmetric reactions, is reported. This very simple synthetic methodology, through reduction or alkylation of an intermediate benzoxazine, was performed in mild conditions, suitable for the conservation of the configuration of the stereogenic centres. Some crystalline aminophenols show the phenomenon of ‘crystallization-induced asymmetric transformation’.
2001
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/250346
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