The first synthesis of triacontan-11-ol, a new fatty alcohol isolated from Argemone mexicana, has been realized starting from the nitroaldol reaction of 1-nitroicosane with decanal. Dehydration of the obtained nitroalkanol gives a long-chain nitroalkene which is then reduced to the corresponding nitroalkane. Nef transformation of the latter produces a ketone that is easily reduced to the fatty alcohol 9 in 21% overall yield.
|Titolo:||1-Nitroicosane as the Key Building Block for the First Synthesis of Triacontan-11-ol, A New Fatty Alcohol Isolated from Argemone mexicana|
|Data di pubblicazione:||2005|
|Appare nelle tipologie:||Articolo|