Electrospray ionization mass spectrometry was usefully employed for the characterization of three phosphino copper(I) complexes of medicinal interest. This technique revealed that the original [CuL4]R pro-drugs (L¼hydrophilic tertiary phosphine) underwent dissociation with production of coordinative unsaturated [CuL3]R and [CuL2]R species, which represented key intermediates for the activation of potential biological properties. The more favoured was the displacement of the ligands from the [CuL4]R parent complex, the more favoured was in turn the possibility for the metal ion to directly interact with biological substrates, including pharmacological targets related to cancer proliferation. An inverse correlation between the stability and the cytotoxic activity of the three copper(I) complexes investigated has been clearly established.
The relationship between the electrospray ionizationbehaviour and biological activity of some phosphinoCu(I) complexes
PELLEI, Maura;
2010-01-01
Abstract
Electrospray ionization mass spectrometry was usefully employed for the characterization of three phosphino copper(I) complexes of medicinal interest. This technique revealed that the original [CuL4]R pro-drugs (L¼hydrophilic tertiary phosphine) underwent dissociation with production of coordinative unsaturated [CuL3]R and [CuL2]R species, which represented key intermediates for the activation of potential biological properties. The more favoured was the displacement of the ligands from the [CuL4]R parent complex, the more favoured was in turn the possibility for the metal ion to directly interact with biological substrates, including pharmacological targets related to cancer proliferation. An inverse correlation between the stability and the cytotoxic activity of the three copper(I) complexes investigated has been clearly established.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
