The Authors report the results of fecal occult blood testing obtained in a sample of selected subjects, evaluating a new immunological test (Hemodia), this was used; with other parameters linked to the risk of developing colorectal cancer (personal history, family history, risk conditions resulting from diagnostic-instrumental examinations} and drawn from informative questionnaires compiled by each patient. An evaluation of the test sensitivity and specificity has been derived from the concordances and discordances of the results compared with another parameter (fourfold Table: 2X2); the statistical processing has been carried out using the Pearson's chi-square (X2) Test (p <= 0,05). The statistical analysis made by comparing the immunological test and personal history showed a X2 = 14.91 (p <= 0.001), sensibility = 63% and specificity = 84%; also the results of the comparison between the Hemodia test and instrumental examinations showed statistical significance (X2 = 6.73; p <= 0.01) and good sensibility (70.5%) and specificity (80%) values. The immunological test, compared with family history, showed no statistical significance. The Authors emphasize the importance of using the personal informative questionnaire that, considering the possible intermittence or the often slight entity of bleeding from many precancerous lesions, could be an effective instrument in planning the repetition and frequency of further investigations or in completing the diagnosis with instrumental examinations.
Fecal occult blood testing in the earlier detection of colorectal cancer: specificity and sensitivity evaluation of a new immunological test
COCCHIONI, Mario;GRAPPASONNI, Iolanda;
1989-01-01
Abstract
The Authors report the results of fecal occult blood testing obtained in a sample of selected subjects, evaluating a new immunological test (Hemodia), this was used; with other parameters linked to the risk of developing colorectal cancer (personal history, family history, risk conditions resulting from diagnostic-instrumental examinations} and drawn from informative questionnaires compiled by each patient. An evaluation of the test sensitivity and specificity has been derived from the concordances and discordances of the results compared with another parameter (fourfold Table: 2X2); the statistical processing has been carried out using the Pearson's chi-square (X2) Test (p <= 0,05). The statistical analysis made by comparing the immunological test and personal history showed a X2 = 14.91 (p <= 0.001), sensibility = 63% and specificity = 84%; also the results of the comparison between the Hemodia test and instrumental examinations showed statistical significance (X2 = 6.73; p <= 0.01) and good sensibility (70.5%) and specificity (80%) values. The immunological test, compared with family history, showed no statistical significance. The Authors emphasize the importance of using the personal informative questionnaire that, considering the possible intermittence or the often slight entity of bleeding from many precancerous lesions, could be an effective instrument in planning the repetition and frequency of further investigations or in completing the diagnosis with instrumental examinations.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
