A horse with chronic respiratory disease was euthanized for diagnostic purposes. Necropsy revealed the presence of multiple masses arising from the right lung, with deep involvement of the main bronchus. Granular cell tumour was diagnosed histologically. Immunohistochemical investigations using both monoclonal (vimentin, neuron-specific enolase, pan-cytokeratins, desmin, synaptophysin) and polyclonal (lysozime, glial fibrillary acid protein, S100) antibodies were carried out. Positivity for vimentin, neuron-specific enolase, S100 was expressed by all the granular cells. Some clusters of cells gave positive reaction also for glial fibrillary acid protein antibody. Granular cells were characterized ultrastructurally by membrane-bound, electrondense granules. These findings support the Schwann cell origine for this equine pulmonary granular cell tumour.
Pulmonary granular cells tumour in a horse: anatomohistopathological, immunohistochemical and ultrastructural investigations.
ROSSI, Giacomo;RENZONI, Giacomo
1997-01-01
Abstract
A horse with chronic respiratory disease was euthanized for diagnostic purposes. Necropsy revealed the presence of multiple masses arising from the right lung, with deep involvement of the main bronchus. Granular cell tumour was diagnosed histologically. Immunohistochemical investigations using both monoclonal (vimentin, neuron-specific enolase, pan-cytokeratins, desmin, synaptophysin) and polyclonal (lysozime, glial fibrillary acid protein, S100) antibodies were carried out. Positivity for vimentin, neuron-specific enolase, S100 was expressed by all the granular cells. Some clusters of cells gave positive reaction also for glial fibrillary acid protein antibody. Granular cells were characterized ultrastructurally by membrane-bound, electrondense granules. These findings support the Schwann cell origine for this equine pulmonary granular cell tumour.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
