The reaction of nitroalkanes with 2-chloro-3-phenylsulfonylpropanenitrile, in the presence of three equivalents of DBU at −10°C, allows the synthesis of polyfunctionalized α,β-unsaturated nitriles. The method proceeds through three different reactions carried out in a tandem sequence, allowing the one-pot formation of the α,β-unsaturated nitriles, generally, with complete E stereochemistry.
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Titolo: | One-pot synthesis of polyfunctionalized, alpha, beta-unsaturated nitriles from nitroalkanes | |
Autori: | ||
Data di pubblicazione: | 2003 | |
Rivista: | ||
Abstract: | The reaction of nitroalkanes with 2-chloro-3-phenylsulfonylpropanenitrile, in the presence of three equivalents of DBU at −10°C, allows the synthesis of polyfunctionalized α,β-unsaturated nitriles. The method proceeds through three different reactions carried out in a tandem sequence, allowing the one-pot formation of the α,β-unsaturated nitriles, generally, with complete E stereochemistry. | |
Handle: | http://hdl.handle.net/11581/242323 | |
Appare nelle tipologie: | Articolo |
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