BL-S 578 (Cefadroxil) is a new orally active semisynthetic cephalosporin antibiotic with broad-spectrum antibacterial activity. The new compound was evaluated in vitro in comparison with cephalexin. Some properties studied such as, antibacterial activity, binding with serum proteins and stability in acid and neutral solution at 37° C for both cephalosporins were similar. In experimental infections of mice, the protective action of BL-S 578 was more effective than cephalexin against Staphylococcus aureus and Streptococcus pneumoniae. BL-S 578 was more resistant than cephalexin to the β-lactamases produced by Klebsiella pneumoniae and Escherichia coli.
Laboratory studies with BL-S 578 (Cefadroxil) a new broad-spectrum orally active cephalosporin
RIPA, Sandro;PRENNA, Manuela
1980-01-01
Abstract
BL-S 578 (Cefadroxil) is a new orally active semisynthetic cephalosporin antibiotic with broad-spectrum antibacterial activity. The new compound was evaluated in vitro in comparison with cephalexin. Some properties studied such as, antibacterial activity, binding with serum proteins and stability in acid and neutral solution at 37° C for both cephalosporins were similar. In experimental infections of mice, the protective action of BL-S 578 was more effective than cephalexin against Staphylococcus aureus and Streptococcus pneumoniae. BL-S 578 was more resistant than cephalexin to the β-lactamases produced by Klebsiella pneumoniae and Escherichia coli.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
