BL-S 786 (Ceforanide) a new injectable semisynthetic cephalosporin, was administered to 10 human volunteers b.d. for 5 days i.m. and i.v. Serum levels were determined after the first, fifth and ninth dose. Urinary excretion was determined in all subjects after the first dose 0-3; 3-6; 6-9; 9-12; 12-24 hr after administration. For i.m. administration peak serum was achieved within 1 hr and detected up to 12 hr after the dose. For i.v. administration, peak serum was achieved within 0.5 hr and detected up to 12 hr after the dose. The serum concentration of BL-S 786, after repeated doses, did not demonstrate accumulation of the drug. About 27 to 36% of the administered dose was excreted unaltered in the urine, within 3 hr of a single parenteral dose. Urine concentration exceeded the minimal inhibitory concentration for 90-100% of the common Gram-negative urinary pathogens, 12 hr after the administered dose.
Pharmacokinetic properties of BL-S 786 (ceforanide) in human volunteers
RIPA, Sandro;PRENNA, Manuela;
1981-01-01
Abstract
BL-S 786 (Ceforanide) a new injectable semisynthetic cephalosporin, was administered to 10 human volunteers b.d. for 5 days i.m. and i.v. Serum levels were determined after the first, fifth and ninth dose. Urinary excretion was determined in all subjects after the first dose 0-3; 3-6; 6-9; 9-12; 12-24 hr after administration. For i.m. administration peak serum was achieved within 1 hr and detected up to 12 hr after the dose. For i.v. administration, peak serum was achieved within 0.5 hr and detected up to 12 hr after the dose. The serum concentration of BL-S 786, after repeated doses, did not demonstrate accumulation of the drug. About 27 to 36% of the administered dose was excreted unaltered in the urine, within 3 hr of a single parenteral dose. Urine concentration exceeded the minimal inhibitory concentration for 90-100% of the common Gram-negative urinary pathogens, 12 hr after the administered dose.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
