The pharmacokinetics of ceforanide, a new cephalosporin, were examined after intravenous injection of 250, 500 and 1000 mg of the drug to healthy human volunteers. The pharmacokinetic parameters show that ceforanide produces higher and longer-lasting serum concentrations than some other cephalosporins and that it is eliminated in the urine to a great extent. The serum and biological half-lives are fairly high. The pharmacokinetics of ceforanide are dose independent, and between slopes (β) of dose/time lines no significant differences exist, while significant differences between intercepts (B0) exist.

Ceforanide: Human pharmacokinetics after I.V. injection

RIPA, Sandro;PRENNA, Manuela;
1982-01-01

Abstract

The pharmacokinetics of ceforanide, a new cephalosporin, were examined after intravenous injection of 250, 500 and 1000 mg of the drug to healthy human volunteers. The pharmacokinetic parameters show that ceforanide produces higher and longer-lasting serum concentrations than some other cephalosporins and that it is eliminated in the urine to a great extent. The serum and biological half-lives are fairly high. The pharmacokinetics of ceforanide are dose independent, and between slopes (β) of dose/time lines no significant differences exist, while significant differences between intercepts (B0) exist.
1982
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/242239
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