Symmetrically N,N′-substituted ureas were obtained from primary amines in very good yields under solvent-less conditions using diethyl carbonate (DEC) as the carbonylation reagent and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the base catalyst. The products are precipitated directly from the reaction mixture after a volatile organic compound (VOC) free aqueous work-up. The catalyst can be recovered and reused.
TBD-catalysed solventless synthesis of symmetrically N,N′-substituted ureas from primary amines and diethyl carbonate
BALLINI, Roberto;FIORINI, Dennis;
2003-01-01
Abstract
Symmetrically N,N′-substituted ureas were obtained from primary amines in very good yields under solvent-less conditions using diethyl carbonate (DEC) as the carbonylation reagent and 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) as the base catalyst. The products are precipitated directly from the reaction mixture after a volatile organic compound (VOC) free aqueous work-up. The catalyst can be recovered and reused.File in questo prodotto:
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