The reaction of linear α-nitro ketones with primary amines allows the formation of amides through the cleavage of the carbon–carbon bond between the carbonyl group and the carbon-nitro group moiety, promoted by the nucleophilic effect of the amine. The reaction is performed at room temperature, without any catalyst and/or solvent.
Uncatalyzedconversion of linear α-nitro ketones into amides by reaction with primary amines under solventless conditions
BALLINI, Roberto;BOSICA, Giovanna;FIORINI, Dennis
2003-01-01
Abstract
The reaction of linear α-nitro ketones with primary amines allows the formation of amides through the cleavage of the carbon–carbon bond between the carbonyl group and the carbon-nitro group moiety, promoted by the nucleophilic effect of the amine. The reaction is performed at room temperature, without any catalyst and/or solvent.File in questo prodotto:
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