Lung uptake,metabolism and release of amines has been experimentally documented. We studied in rabbit and man the lung kinetics of radioiodinated N-N-N'-trimethyl-N--(2-hydroxy-3-methyl-5-iodobenzyl) -1,3-propanediamine (HIPDM) in rabbits,after i.v.injection, 95% of HIPDM is kept within the lungs and is then released with a mean time (E) of several hours as assessed both in vivo, by gamma camera external counting (n=5,t=7.0hrs), and in vitro by measuring activity in lung homogenates at various times after injection (n=56,.t=7.6 hrs). In 10 healthy non smoking subjects t was 6.4+/-1 hrs, whereas it was 12.1±2hrs in 10 asymptomatic smokers with normal pulmonary function tests. Preliminary clinical studies showed that HIPDM lung release is delayed in non smoking patients with primary pulmonary hypertension(n=4,E=U.5t2hrs) and to a greater extent L adult respiratory distress syndrome (n-4;E-25 8+5 hrs) whereas it was not significantly affected in cardiogenic pulmonary edema (n=4; t=8. 8±2 hrs). Hence both smoke exposure and injury to the lung microcir- culation may impair HIPDM lung kinetics. HIPDM external counting may therefore provide a new index of lung dysfunc- tion in man. Rabbit can be used as a model to evaluate HIPDM lung kinetAcs in experimentally induced lung injury.
Lung release of HIPDM: a new index of lung dysfunction for clinical and experimental studies.
RENZONI, Giacomo;
1985-01-01
Abstract
Lung uptake,metabolism and release of amines has been experimentally documented. We studied in rabbit and man the lung kinetics of radioiodinated N-N-N'-trimethyl-N--(2-hydroxy-3-methyl-5-iodobenzyl) -1,3-propanediamine (HIPDM) in rabbits,after i.v.injection, 95% of HIPDM is kept within the lungs and is then released with a mean time (E) of several hours as assessed both in vivo, by gamma camera external counting (n=5,t=7.0hrs), and in vitro by measuring activity in lung homogenates at various times after injection (n=56,.t=7.6 hrs). In 10 healthy non smoking subjects t was 6.4+/-1 hrs, whereas it was 12.1±2hrs in 10 asymptomatic smokers with normal pulmonary function tests. Preliminary clinical studies showed that HIPDM lung release is delayed in non smoking patients with primary pulmonary hypertension(n=4,E=U.5t2hrs) and to a greater extent L adult respiratory distress syndrome (n-4;E-25 8+5 hrs) whereas it was not significantly affected in cardiogenic pulmonary edema (n=4; t=8. 8±2 hrs). Hence both smoke exposure and injury to the lung microcir- culation may impair HIPDM lung kinetics. HIPDM external counting may therefore provide a new index of lung dysfunc- tion in man. Rabbit can be used as a model to evaluate HIPDM lung kinetAcs in experimentally induced lung injury.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.