A series of 2',3'-dideoxy-N6-(cyclo)alkyl-1-deazaadenosine derivs. were synthesized starting from 2,6-dichloro-1-deazapurine. The new nucleosides proved to be good inhibitors of HIV-1 replication, the most active being 2',3'-dideoxy-2-chloro-N6-cycloctyl-1-deazaadenosine (ED50 = 0.4 μM).
Inhibitory effects of 1-deazaadenosine analogs of HIV replication and adenosine deaminase
VITTORI, Sauro;VOLPINI, Rosaria;CRISTALLI, Gloria
1995-01-01
Abstract
A series of 2',3'-dideoxy-N6-(cyclo)alkyl-1-deazaadenosine derivs. were synthesized starting from 2,6-dichloro-1-deazapurine. The new nucleosides proved to be good inhibitors of HIV-1 replication, the most active being 2',3'-dideoxy-2-chloro-N6-cycloctyl-1-deazaadenosine (ED50 = 0.4 μM).File in questo prodotto:
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