5,7-Dichloro-3H-imidazo[4,5-b]pyridine (4) is a versatile base which can be coupled with a variety of sugar moieties and transformed in a series of 7-alkyl(aryl)amino-derivatives by reacting with the corresponding amines. In this paper synthesis, structure elucidation and ADA inhibitory activity of 2'- deoxyribonucleoside derivatives of N6- substituted 1 -deazaapurines are described.
SYNTHESIS OF 2'-DEOXYRIBONUCLEOSIDE DERIVATIVESOF I-DEAZAPURINE
VITTORI, Sauro;VOLPINI, Rosaria;LUPIDI, Giulio
1994-01-01
Abstract
5,7-Dichloro-3H-imidazo[4,5-b]pyridine (4) is a versatile base which can be coupled with a variety of sugar moieties and transformed in a series of 7-alkyl(aryl)amino-derivatives by reacting with the corresponding amines. In this paper synthesis, structure elucidation and ADA inhibitory activity of 2'- deoxyribonucleoside derivatives of N6- substituted 1 -deazaapurines are described.File in questo prodotto:
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