Propargyl bromide was converted to the resp. allenylmagnesium bromide and added to nitro compds. to give N-aryl-N propargylhydroxylamines and N-alkyl-N-propargylhydroxylamines RN(CH2C≡CH)OH I (R = Ph, 4-ClC6H4, 1-naphthyl, hexyl, cyclohexyl, 4-MeC6H4CH2CH2 etc.) in the presence of LiAlH4 and Pd/C. I are not further reduced to give, e.g., N-propargylanilines.
Reaction of Nitro Compounds toward Grignard Reagents. A general method of synthesis of N-Alkyl or N-Aryl-Propargylhydroxylamines
BARTOLI, Giuseppe;PALMIERI, Gianni;PETRINI, Marino;
1990-01-01
Abstract
Propargyl bromide was converted to the resp. allenylmagnesium bromide and added to nitro compds. to give N-aryl-N propargylhydroxylamines and N-alkyl-N-propargylhydroxylamines RN(CH2C≡CH)OH I (R = Ph, 4-ClC6H4, 1-naphthyl, hexyl, cyclohexyl, 4-MeC6H4CH2CH2 etc.) in the presence of LiAlH4 and Pd/C. I are not further reduced to give, e.g., N-propargylanilines.File in questo prodotto:
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