The effects of mammalian gonadotropin-releasing hormone on ovarian release of progesterone, androgens and estradiol-17 beta were studied in vitro by a superfusion system carried out on follicles of adult female Rana esculenta, collected at different periods of the annual reproductive cycle. The follicles were superfused with medium alone, pituitary, mammalian gonadotropin-releasing hormone, or pituitary plus mammalian gonadotropin-releasing hormone. For follicles obtained in the prereproductive period, pituitary plus mammalian gonadotropin-releasing hormone increased the estradiol values much more than pituitary alone. In the reproductive period, pituitary alone increased the estradiol values much more than pituitary plus mammalian gonadotropin-releasing hormone. For follicles obtained in the recovery period, mammalian gonadotropin-releasing hormone alone stimulated the highest estradiol production, and pituitary plus mammalian gonadotropin-releasing hormone increased the estradiol values much more than pituitary alone. The results reported here suggest that mammalian gonadotropin-releasing hormone and/or pituitary have a direct effect on ovarian estradiol secretion, and that this effect varies with the annual reproductive cycle.

In vitro steroid production by follicles of frog Rana esculenta: mammalian gonadotropin-releasing hormone effects.

ZERANI, Massimo;GOBBETTI, Anna;
1991-01-01

Abstract

The effects of mammalian gonadotropin-releasing hormone on ovarian release of progesterone, androgens and estradiol-17 beta were studied in vitro by a superfusion system carried out on follicles of adult female Rana esculenta, collected at different periods of the annual reproductive cycle. The follicles were superfused with medium alone, pituitary, mammalian gonadotropin-releasing hormone, or pituitary plus mammalian gonadotropin-releasing hormone. For follicles obtained in the prereproductive period, pituitary plus mammalian gonadotropin-releasing hormone increased the estradiol values much more than pituitary alone. In the reproductive period, pituitary alone increased the estradiol values much more than pituitary plus mammalian gonadotropin-releasing hormone. For follicles obtained in the recovery period, mammalian gonadotropin-releasing hormone alone stimulated the highest estradiol production, and pituitary plus mammalian gonadotropin-releasing hormone increased the estradiol values much more than pituitary alone. The results reported here suggest that mammalian gonadotropin-releasing hormone and/or pituitary have a direct effect on ovarian estradiol secretion, and that this effect varies with the annual reproductive cycle.
1991
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/218775
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