In rabbits, several intraluteal pathways have emerged as potential mediators of the luteolytic action of prostaglandin F2αPGF2α, but the mechanisms that protect the developing corpora lutea (CL) from functional luteolysis to occur up to day 5 of pseudopregnancy are still unclear. Thus, the aim of this study was to elucidate PGF2α-induced temporal expression changes for estrogen receptor (ERα), interleukin-1(IL-1β), p53, and Bcl-x genes in day 4 vs. day 9 CL, in order to further characterize their role in the acquisition of luteal capacity to PGF2α. In conclusion, these findings suggest that PGF2α regulates luteolysis by ERαmRNA downregulation and by modulation of pro- and antiapoptotic pathways in CL that have acquired luteolytic capacity.
Luteal estrogen receptor, interleukin-1, and apoptosis-associated genes during prostaglandin F2 alpha-induced luteolysis in rabbits at different stages of pseudopregnancy
ZERANI, Massimo;GOBBETTI, Anna;
2008-01-01
Abstract
In rabbits, several intraluteal pathways have emerged as potential mediators of the luteolytic action of prostaglandin F2αPGF2α, but the mechanisms that protect the developing corpora lutea (CL) from functional luteolysis to occur up to day 5 of pseudopregnancy are still unclear. Thus, the aim of this study was to elucidate PGF2α-induced temporal expression changes for estrogen receptor (ERα), interleukin-1(IL-1β), p53, and Bcl-x genes in day 4 vs. day 9 CL, in order to further characterize their role in the acquisition of luteal capacity to PGF2α. In conclusion, these findings suggest that PGF2α regulates luteolysis by ERαmRNA downregulation and by modulation of pro- and antiapoptotic pathways in CL that have acquired luteolytic capacity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
