NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme.
Synthesis and Biological Evaluation of NAD Analogs as Human Pyridine Nucleotide Adenylyltransferase Inhibitors
FRANCHETTI, Palmarisa;PETRELLI, Riccardo;CAPPELLACCI, Loredana;VITA, PATRIZIA;
2005-01-01
Abstract
NAD analogs modified at the ribose adenylyl moiety, named N-2'-MeAD and Na-2'-MeAD, were synthesized as ligands of pyridine nucleotide (NMN/NaMN) adenylyltransferase (NMNAT). Both dinucleotides resulted selective inhibitors against human NMNAT-3 isoenzyme.File in questo prodotto:
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