In Rana esculenta in an in vitro system, hepatic vitellogenin synthesis can be induced by growth hormone in both sexes. In this study: (1) the ability of this hormone to induce transcription of the VTG gene was determined, and (2) this ability was compared with that of estradiol-17β. The results indicate that growth hormone stimulates VTG mRNA transcription both in vivo and in vitro, in both sexes. The levels of mRNA are related to protein levels in the medium. In addition, seasonal variation occurs in the VTG gene transcription under growth hormone and estradiol-17β; indeed the more active inducer was growth hormone during the reproductive period and estradiol-17β during the prereproductive phase.
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|Titolo:||Multihormonal control of vitellogenin mRNA expression in the liver of frog, Rana esculenta|
|Data di pubblicazione:||1995|
|Appare nelle tipologie:||Articolo|