A lactose carrier with long TOF was engineered to improve drug deposition from DPIs. The particles were engineered by contacting spray-dried particles with a solvent in which these have a poor solubility. The process increased the particles hollow volume without affecting their original shape. The long TOF was demonstrated by carrier deposition in the lower stage of the TSI, which was up to 9 -fold higher compared to the conventional lactose. The highest deposition of the long TOF carrier was obtained at the lowest inhalation flow rate (24 L/min). The % Fine Particle Fraction of salbutamol sulphate was up to 50% when long TOF carrier was used. Importantly, this study has shown that adhesion drug/carrier has no negative effect on drug deposition, when a long TOF carrier is used.
Engineered Carrier with a Long Time of Flight (TOF) to Improve Drug Delivery From Dry Powder Inhalation Aerosols
CESPI, MARCO;
2007-01-01
Abstract
A lactose carrier with long TOF was engineered to improve drug deposition from DPIs. The particles were engineered by contacting spray-dried particles with a solvent in which these have a poor solubility. The process increased the particles hollow volume without affecting their original shape. The long TOF was demonstrated by carrier deposition in the lower stage of the TSI, which was up to 9 -fold higher compared to the conventional lactose. The highest deposition of the long TOF carrier was obtained at the lowest inhalation flow rate (24 L/min). The % Fine Particle Fraction of salbutamol sulphate was up to 50% when long TOF carrier was used. Importantly, this study has shown that adhesion drug/carrier has no negative effect on drug deposition, when a long TOF carrier is used.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
