Stress is a key determinant of binge eating (BE). Since Rhodiola rosea is known to modulate stress responses, its effect in a model of BE was investigated. BE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/refeeding (for 4 days 66% of the usual chow intake; for 4 days food ad libitum) and acute stress on the test day (day 25). R. rosea dry extract (3% rosavin, 3.12% salidroside) or its active principles were given by gavage 1 h before access to HPF. Only rats exposed to both food restrictions and stress exhibited BE in the first 15–60 min after the stressful procedure. R. rosea extract 10 mg/kg significantly reduced and 20 mg/kg abolished the BE episode. R. rosea extract 20 mg/kg abolished also stress-induced increase in serum corticosterone levels. The R. rosea active principle salidroside, but not rosavin, at doses present in the extract, dose-dependently reduced or abolished BE for the period in which it was elicited. In conclusion results indicate that R. rosea extracts may have therapeutic properties in bingeing-related eating disorders and that salidroside is the active principle responsible for this effect.

Effect of Salidroside, active principle of Rhodiola rosea extract, on binge eating.

CIFANI, Carlo;MICIONI DI BONAVENTURA, Maria Vittoria;CICCOCIOPPO, Roberto;MASSI, Maurizio
2010-01-01

Abstract

Stress is a key determinant of binge eating (BE). Since Rhodiola rosea is known to modulate stress responses, its effect in a model of BE was investigated. BE for highly palatable food (HPF) was evoked in female rats by three 8-day cycles of food restriction/refeeding (for 4 days 66% of the usual chow intake; for 4 days food ad libitum) and acute stress on the test day (day 25). R. rosea dry extract (3% rosavin, 3.12% salidroside) or its active principles were given by gavage 1 h before access to HPF. Only rats exposed to both food restrictions and stress exhibited BE in the first 15–60 min after the stressful procedure. R. rosea extract 10 mg/kg significantly reduced and 20 mg/kg abolished the BE episode. R. rosea extract 20 mg/kg abolished also stress-induced increase in serum corticosterone levels. The R. rosea active principle salidroside, but not rosavin, at doses present in the extract, dose-dependently reduced or abolished BE for the period in which it was elicited. In conclusion results indicate that R. rosea extracts may have therapeutic properties in bingeing-related eating disorders and that salidroside is the active principle responsible for this effect.
2010
262
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/203243
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 54
  • ???jsp.display-item.citation.isi??? ND
social impact