Practical, cheap, and stereoselective synthetic methods were applied to the preparation of novel 1-(aminoalkyl)naphthol and g-aminoalcohol tridentate ligands. The ligands obtained were conveniently applied with good results as catalytic sources in the borane-mediated enantioselective reduction of acetophenone with borane dimethylsulfide. Conformational analysis through molecular modeling allows the rationalization of observed stereochemical outcomes.
Borane-Mediated Asymmetric Reduction of Acetophenone by Enantiopure Aminonaphthols and Aminoalcohols as Catalytic Source
CIMARELLI, Cristina;FRATONI, DAVIDE;PALMIERI, Gianni
2010-01-01
Abstract
Practical, cheap, and stereoselective synthetic methods were applied to the preparation of novel 1-(aminoalkyl)naphthol and g-aminoalcohol tridentate ligands. The ligands obtained were conveniently applied with good results as catalytic sources in the borane-mediated enantioselective reduction of acetophenone with borane dimethylsulfide. Conformational analysis through molecular modeling allows the rationalization of observed stereochemical outcomes.File in questo prodotto:
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