Diethyl phosphite and diphenylphosphine add to a series of unsaturated derivatives using environmentally-friendly calcium oxide as a basic promoter under solventless conditions at room temperature. The corresponding adducts are obtained in a totally regioselective fashion, via a 1,4-addition on α,β-unsaturated esters and sulfone, and a 1,2-addition on cyclic and acyclic α,β-unsaturated aldehydes and ketones.
|Titolo:||A green procedure for the regio and chemoselective hydrophosphonylation of unsaturated systems using CaO under solventless conditions|
|Data di pubblicazione:||2010|
|Appare nelle tipologie:||Articolo|