Stress is a determinant of binge eating. Rhodiola rosea (ROR) extracts modulate stress responses. The present study evaluated the effect ofRORdry extract and its active principles in rats in which binge eating for highly palatable sweet food (HPF) was evoked by stress and repeated food restrictions. Female Sprague–Dawley rats were submitted to three 8-day cycles of food restriction/refeeding (4 d 66% of the usual chow intake, 4 d food ad libitum) and to acute stress on d25. Stress was induced by preventing access to HPF for 15 min, while rats were able to see and smell it. 4 groups of rats were used: NR+NS rats were normally fed and not stressed on the test day (d25); NR+ S rats were similarly fed but were stressed on d25; R +NS rats were exposed to 3 cycles of yo-yo dieting but not stressed; R + S rats were exposed to 3 cycles of yo-yo dieting and stressed on d25. ROR dry extract (containing 3% rosavin and 3.12% salidroside) or the purified principles were given by gavage 1 h before access to HPF. Food restrictions and stress induced binge eating in R + S rats, increasing HPF intake of about 50% in the first 15 min. 10 mg/kg of ROR extract significantly reduced and 20 mg/kg abolished the HPF binge in R + S rats, but did not modify HPF intake in NR+ NS, NR+ S or R +NS rats. Rosavin or salidroside, 600 or 636g/kg (i.e. the amounts in 20 mg/kg of extract) significantly reduced HPF intake in R + S rats; when given together they completely abolished the binge response. Thus, ROR extracts or its active principles, rosavin and salidroside, may be interesting agents for treatment of bingeing-related eating disorders.
Effect of Rhodiola Rosea extracts on binge eating in female rats
CIFANI, Carlo;MV MICIONI DI BONAVENTURA;
2010-01-01
Abstract
Stress is a determinant of binge eating. Rhodiola rosea (ROR) extracts modulate stress responses. The present study evaluated the effect ofRORdry extract and its active principles in rats in which binge eating for highly palatable sweet food (HPF) was evoked by stress and repeated food restrictions. Female Sprague–Dawley rats were submitted to three 8-day cycles of food restriction/refeeding (4 d 66% of the usual chow intake, 4 d food ad libitum) and to acute stress on d25. Stress was induced by preventing access to HPF for 15 min, while rats were able to see and smell it. 4 groups of rats were used: NR+NS rats were normally fed and not stressed on the test day (d25); NR+ S rats were similarly fed but were stressed on d25; R +NS rats were exposed to 3 cycles of yo-yo dieting but not stressed; R + S rats were exposed to 3 cycles of yo-yo dieting and stressed on d25. ROR dry extract (containing 3% rosavin and 3.12% salidroside) or the purified principles were given by gavage 1 h before access to HPF. Food restrictions and stress induced binge eating in R + S rats, increasing HPF intake of about 50% in the first 15 min. 10 mg/kg of ROR extract significantly reduced and 20 mg/kg abolished the HPF binge in R + S rats, but did not modify HPF intake in NR+ NS, NR+ S or R +NS rats. Rosavin or salidroside, 600 or 636g/kg (i.e. the amounts in 20 mg/kg of extract) significantly reduced HPF intake in R + S rats; when given together they completely abolished the binge response. Thus, ROR extracts or its active principles, rosavin and salidroside, may be interesting agents for treatment of bingeing-related eating disorders.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
