A series of new derivatives, related to diphenidol and to its 2-carbonyl analogue, were designed as antimuscarinic agents. The synthesized compounds were evaluated both as hydrochlorides and as methiodides by functional tests at guinea-pig heart (M2), guinea-pig ileum (M3) and rabbit vas deferens (putative M4). Two derivatives (3a and 5a) showed an M3-selective profile similar to that of the reference compounds, though they resulted less potent.
|Titolo:||Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol|
|Autori interni:||ANGELI, Piero|
|Data di pubblicazione:||2003|
|Appare nelle tipologie:||Articolo|