Activation of GabaA receptors increases [Ca2+]i in frog pituitary melanotropes

Desrues, L.; Tonon, M.C.; Sabbieti, M.G.; POLZONETTI-MAGNI, A.M.; Vazquez, R.M.; Lamacz, M.; Malagon, M.; GRACIA-NAVARRO, F.; Vaudry, H.

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The neurotransmitter GABA regulates the activity of the pars intermedia in mammals and in submammalian vertebrates. In frog melanotrope cells, GABA acting through GABAA receptors causes a biphasic effect, that is, a rapid stimulation followed by a sustained inhibition of alpha MSH secretion. The present study investigates the intracellular events associated with the stimulatory phase of the response to GABA. Although our data demonstrate that, in frog pituitary melanotrophs, the stimulation of alpha-MSH secretion induced by GABA is coupled to a Cl- dependent influx of Ca2+ via nifedipine-sensitive channels.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/201662

Titolo:	Activation of GabaA receptors increases [Ca2+]i in frog pituitary melanotropes
Autori interni:	SABBIETI, Maria Giovanna POLZONETTI, Alberta Maria
Data di pubblicazione:	1998
Rivista:	ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Abstract:	The neurotransmitter GABA regulates the activity of the pars intermedia in mammals and in submammalian vertebrates. In frog melanotrope cells, GABA acting through GABAA receptors causes a biphasic effect, that is, a rapid stimulation followed by a sustained inhibition of alpha MSH secretion. The present study investigates the intracellular events associated with the stimulatory phase of the response to GABA. Although our data demonstrate that, in frog pituitary melanotrophs, the stimulation of alpha-MSH secretion induced by GABA is coupled to a Cl- dependent influx of Ca2+ via nifedipine-sensitive channels.
Handle:	http://hdl.handle.net/11581/201662
Appare nelle tipologie:	Articolo

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