The neurotransmitter GABA regulates the activity of the pars intermedia in mammals and in submammalian vertebrates. In frog melanotrope cells, GABA acting through GABAA receptors causes a biphasic effect, that is, a rapid stimulation followed by a sustained inhibition of alpha MSH secretion. The present study investigates the intracellular events associated with the stimulatory phase of the response to GABA. Although our data demonstrate that, in frog pituitary melanotrophs, the stimulation of alpha-MSH secretion induced by GABA is coupled to a Cl- dependent influx of Ca2+ via nifedipine-sensitive channels.

Activation of GabaA receptors increases [Ca2+]i in frog pituitary melanotropes

SABBIETI, Maria Giovanna;POLZONETTI, Alberta Maria;
1998-01-01

Abstract

The neurotransmitter GABA regulates the activity of the pars intermedia in mammals and in submammalian vertebrates. In frog melanotrope cells, GABA acting through GABAA receptors causes a biphasic effect, that is, a rapid stimulation followed by a sustained inhibition of alpha MSH secretion. The present study investigates the intracellular events associated with the stimulatory phase of the response to GABA. Although our data demonstrate that, in frog pituitary melanotrophs, the stimulation of alpha-MSH secretion induced by GABA is coupled to a Cl- dependent influx of Ca2+ via nifedipine-sensitive channels.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/201662
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact