In the past years, numerous studies of NAD-dependent biological processes have revealed various remarkable roles of NAD in cell biology and medicine. Enzymes utilize NAD for modification of DNA and proteins, formation of signal transduction agents, and as co-enzymes in redox reactions. Molecules affecting interactions of NAD with NAD-dependent or NAD-utilizing enzymes are now of great therapeutic interest ranging from aging to cancer. Herein we present our recent contribution to the new field of NAD-therapeutics.
Novel cofactor-type inhibitors of NAD-dependent enzymes. NAD-based therapeutics.
PETRELLI, Riccardo;
2008-01-01
Abstract
In the past years, numerous studies of NAD-dependent biological processes have revealed various remarkable roles of NAD in cell biology and medicine. Enzymes utilize NAD for modification of DNA and proteins, formation of signal transduction agents, and as co-enzymes in redox reactions. Molecules affecting interactions of NAD with NAD-dependent or NAD-utilizing enzymes are now of great therapeutic interest ranging from aging to cancer. Herein we present our recent contribution to the new field of NAD-therapeutics.File in questo prodotto:
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