DNA release from cationic liposome/DNA complexes by anionic lipids

Caracciolo, G; Pozzi, D; Caminiti, R; Marchini, Cristina; Montani, Maura; Amici, Augusto; Amenitsch, H.

The authors found that recently developed multicomponent cationic liposome DNA complexes (lipoplexes) exhibit higher transfection efficiency with respect to usually employed binary lipoplexes in NIH 3T3 and A17 cell lines. Interaction of lipoplexes with anionic liposomes (model of cellular membranes) was investigated by synchrotron small angle x-ray diffraction. The authors used one-dimensional DNA packing density to estimate the molar fraction of DNA released from lipoplexes by anionic lipids.

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Titolo:	DNA release from cationic liposome/DNA complexes by anionic lipids
Autori:	CARACCIOLO G POZZI D CAMINITI R MARCHINI, Cristina MONTANI, Maura AMICI, Augusto AMENITSCH H. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2006
Rivista:	APPLIED PHYSICS LETTERS
Abstract:	The authors found that recently developed multicomponent cationic liposome DNA complexes (lipoplexes) exhibit higher transfection efficiency with respect to usually employed binary lipoplexes in NIH 3T3 and A17 cell lines. Interaction of lipoplexes with anionic liposomes (model of cellular membranes) was investigated by synchrotron small angle x-ray diffraction. The authors used one-dimensional DNA packing density to estimate the molar fraction of DNA released from lipoplexes by anionic lipids.
Handle:	http://hdl.handle.net/11581/115712
Appare nelle tipologie:	Articolo

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