The purpose of this review is to discuss the effect of natural antioxidantcompounds as modulators of the 20S proteasome, a multi-enzymatic multicatalytic complex present in the cytoplasm and nucleus of eukaryotic cells and involved in several cellular activities such as cell-cycle progression, proliferation and the degradation of oxidized and damaged proteins. From this perspective, proteasome inhibition is a promising approach to anticancer therapy and such natural antioxidant effectors can be considered as potential relevant adjuvants and pharmacological models in the study of new drugs.
|Titolo:||Natural polyphenols as proteasome modulators and their role as anti-cancer compounds|
|Autori interni:||BONFILI, LAURA|
ELEUTERI, Anna Maria
|Data di pubblicazione:||2008|
|Rivista:||THE FEBS JOURNAL|
|Appare nelle tipologie:||Articolo|