In the last years the dosage of serum cystatin C (CCs) became an interesting marker of renal function (FR). In the present work we used a particle-enhanced nephelometric immunoassay (PENIA – human antibodies) to determine this concentration in healthy dogs and in dogs affected by renal insufficiency (increased serum creatinine, urea nitrogen and phosphate). We have also made kidney biopsies in this subjects and we have then correlated the histologic appearance to CCs and creatinine dosages in order to point out any correlation. Our preliminary data confirm that CCs is a good marker of FR and show that it could also be a prospective indicator helpful to differentiate renal dysfunctions between themselves.

Dosaggio della cistatina C sierica in cani con insufficienza renale e suo raffronto con i reperti istologici – risultati preliminari

CERQUETELLA, Matteo;FRUGANTI, Alessandro;SPATERNA, Andrea
2008-01-01

Abstract

In the last years the dosage of serum cystatin C (CCs) became an interesting marker of renal function (FR). In the present work we used a particle-enhanced nephelometric immunoassay (PENIA – human antibodies) to determine this concentration in healthy dogs and in dogs affected by renal insufficiency (increased serum creatinine, urea nitrogen and phosphate). We have also made kidney biopsies in this subjects and we have then correlated the histologic appearance to CCs and creatinine dosages in order to point out any correlation. Our preliminary data confirm that CCs is a good marker of FR and show that it could also be a prospective indicator helpful to differentiate renal dysfunctions between themselves.
2008
262
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/113869
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