Two dinucleoside polyphosphate NAD analogs, P-1-(adenosine-5')-P-3-(nicotinamide riboside-5')triphosphate (Np(3)A, 1) and P-1-(adenosine-5')-P-4-(nicotinamide riboside-5')tetraphosphate (Np(4)A, 2), were synthesized and tested as inhibitors of both microbial and human recombinant NMN adenylyltransferase. Compounds 1 and 2 proved to be selective inhibitors of microbial enzymes.
Dinucleoside polyphosphate NAD analogs as potential NMN adenylyltransferase inhibitors. Synthesis and biological evaluation
FRANCHETTI, Palmarisa;CAPPELLACCI, Loredana;GRIFANTINI, Mario;
2003-01-01
Abstract
Two dinucleoside polyphosphate NAD analogs, P-1-(adenosine-5')-P-3-(nicotinamide riboside-5')triphosphate (Np(3)A, 1) and P-1-(adenosine-5')-P-4-(nicotinamide riboside-5')tetraphosphate (Np(4)A, 2), were synthesized and tested as inhibitors of both microbial and human recombinant NMN adenylyltransferase. Compounds 1 and 2 proved to be selective inhibitors of microbial enzymes.File in questo prodotto:
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