Friedel-Crafts reaction of indoles with r-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl)indoles in good yield. The obtained products can be further desulfonylated under reductive or alkylative conditions giving linear and branched 3-substituted indoles.
Solventless clay-promoted Friedel-Crafts reaction of indoles with alpha-amido sulfones: Unexpected synthesis of 3-(1-arylsulfonylalkyl) indoles
BALLINI, Roberto;PALMIERI, Alessandro;PETRINI, Marino;TORREGIANI, Elisabetta
2006-01-01
Abstract
Friedel-Crafts reaction of indoles with r-amido sulfones in the presence of montmorillonite K-10 leads unexpectedly to 3-(1-arylsulfonylalkyl)indoles in good yield. The obtained products can be further desulfonylated under reductive or alkylative conditions giving linear and branched 3-substituted indoles.File in questo prodotto:
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