Basic alumina is found to promote the conjugate addition of indoles to nitroalkenes in solventless conditions at 60° C. Nitroalkenes can be replaced by nitro alcohols that are converted into nitroolefins under the reaction conditions. Alternatively, a tandem nitroaldol-dehydration allows the utilization of nitroalkanes and aldehydes as remote precursors of reactive nitroalkenes in a one – pot synthesis of 3-substituted indoles.
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Titolo: | Conjugate addition of indoles to nitroalkenes promoted by basic alumina in solventless conditions |
Autori: | |
Data di pubblicazione: | 2006 |
Rivista: | |
Abstract: | Basic alumina is found to promote the conjugate addition of indoles to nitroalkenes in solventless conditions at 60° C. Nitroalkenes can be replaced by nitro alcohols that are converted into nitroolefins under the reaction conditions. Alternatively, a tandem nitroaldol-dehydration allows the utilization of nitroalkanes and aldehydes as remote precursors of reactive nitroalkenes in a one – pot synthesis of 3-substituted indoles. |
Handle: | http://hdl.handle.net/11581/113279 |
Appare nelle tipologie: | Articolo |
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