Starting from 10-deacetylbaccatin 111 (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanes
Synthesis and Biological Evaluation of Methoxylated Analogs of the Newer Generation Taxoids IDN5109 and IDN5390
BARBONI, Luciano;BALLINI, Roberto;GIARLO, Guido;
2005-01-01
Abstract
Starting from 10-deacetylbaccatin 111 (7), the 2-debenzoyl-2-m-methoxybenzoyl analogs of the newer generation taxoids IDN5109 (3) and IDN5390 (4) were synthesized. The biological evaluation of these compounds (5 and 6, respectively) showed a general increase of cytotoxicity, as observed in first-generation anticancer taxanesFile in questo prodotto:
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